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C CARDIOVASCULAR SYSTEMThis group comprises substances used for the treatment of cardiovascular conditions.
Drugs used for the treatment of hypertension are classified in C02 - Antihypertensives, C03 - Diuretics, C07 - Beta blocking agents, C08 - Calcium channel blockers, and C09 - Agents acting on the renin-angiotensin system. For the classification of combination products of antihypertensives from different ATC groups, the following ranking should be used, from higher to lower precedence: C09, C07, C08, and C03.
C08 CALCIUM CHANNEL BLOCKERS
The calcium channel blockers are classified according to selectivity of calcium channel activity and direct cardiac effects. The ATC 4th levels are subdivided according to chemical structure.
Combinations with ergot alkaloids (C04AE) are classified in this group by using the 50-series.
Combinations with diuretics are classified in C08G.
Combinations with ACE inhibitors are classified in C09BB.
Combinations with beta blocking agents are classified in C07FB.
Combinations with statins are classified in C10BX.
| The DDDs for calcium channel blockers are based on the treatment of mild-moderate hypertension, although some are used for other indications (e.g. angina pectoris). The DDDs for oral and parenteral preparations are equal and are based on the oral dose, since oral preparations represent the major fraction of the total consumption. |
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
Preparations containing nifedipine in combination with ergot alkaloids are classified in C08CA55.
Combinations with diuretics are classified in C08G.
Amlodipine in combination with atorvastatin is classified in C10BX03.
| ATC code | Name | DDD | U | Adm.R | Note |
| C08CA11 | manidipine | 10 | mg | O |
Last updated: 2024-01-26