Postal address:
Norwegian Institute of Public Health
WHO Collaborating Centre for Drug Statistics Methodology
Postboks 222 Sk°yen
0213 Oslo

Visiting/delivery address:
Myrens verksted 6H
0473 Oslo

Tel:  +47 21 07 81 60

New search    Hide text from Guidelines


The group is divided into therapeutic subgroups:
N05A - Antipsychotics
N05B - Anxiolytics
N05C - Hypnotics and sedatives


This group comprises drugs with antipsychotic actions (i.e. neuroleptics).
Reserpine is classified in C02 - Antihypertensives.
Antipsychotics in combination with antidepressants are classified in N06C - Psycholeptics and psychoanaleptics in combination.
The group is subdivided mainly according to chemical structure.

The DDDs are based on the treatment of psychosis. The substances in this group are sometimes used for other indications in much lower doses.
For depot injections, the DDDs are based on the average recommended doses divided by the dosing interval.


This group comprises preparations used in the treatment of neuroses and psychosomatic disorders associated with anxiety and tension, e.g. benzodiazepines.
See also:
N05A - Antipsychotics
N05C - Hypnotics and sedatives
Usually the presence of an anxiolytic (or other psycholeptics) in combined preparations must be regarded as being of secondary importance and the preparations should be classified in the respective therapeutic groups (e.g. A03C - Antispasmodics in combination with psycholeptics, N02 - Analgesics).
Combined preparations used mainly for the treatment of anxiety are classified at separate 5th levels using the corresponding 50-series.
The group is subdivided according to chemical structure.

The DDDs are based on the treatment of anxiety.


This group comprises preparations with mainly sedative or hypnotic actions.
Melatonin receptor agonists are also classified in this group.
See also:
N05A - Antipsychotics
N05B - Anxiolytics
R06A - Antihistamines for systemic use
Combined preparations are classified at separate 4th levels, N05CB and N05CX.
Regarding classification of combined preparations, see comments under N05B - Anxiolytics.
Combined preparations with barbiturates are mainly classified in A03 (mainly antispasmodic effect) or in N02 (mainly analgesic effect).
Combined preparations with barbiturates which remain in N05C are mainly "neurostabilizers".
The group is subdivided according to chemical structure.

The DDDs are based on use of the drugs as hypnotics.
The DDD for melatonin is based on dose recommendations in EU for the 2 mg depot tablet.

Last updated: 2024-01-26