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L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTSThis group comprises preparations used in the treatment of neoplastic diseases, and immunomodulating agents.
Corticosteroids for systemic use, see H02.
L01 ANTINEOPLASTIC AGENTS
Combination products are classified in L01XY - Combinations of antineoplastic agents, except for combinations of monoclonal antibodies or antibody drug conjugates which are classified in L01FY.
Detoxifying agents used in connection with high dose treatment of antineoplastic agents are classified in V03AF (e.g. calcium folinate).
Radiopharmaceuticals used in the treatment of cancer are classified in V10X.
| DDDs have been established for the protein kinase inhibitors in L01E only. No DDDs have been established for substances classified in ATC 3rd level L01A, L01B, L01C, L01D, L01F or L01X. This is because of highly individualised use and wide dosage ranges. The doses used vary substantially because of various types and severity of neoplastic diseases, and also because of the extensive use of combination therapy. The consumption of antineoplastic agents is in some countries measured in grams. This is recommended as a method to be used internationally for these particular agents. |
L01A ALKYLATING AGENTS
L01B ANTIMETABOLITES
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
L01E PROTEIN KINASE INHIBITORS
This group comprises protein kinase inhibitors used for neoplastic diseases. Substances are classified according to their main target.
Substances which are multi-targeted without a clear main target are classified in L01EX.
Lipid kinase inhibitors (phosphatidylinositol-3-kinase (Pi3K) inhibitors) are classified in L01EM.
L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
Monoclonal antibodies mainly indicated for the treatment of cancer are classified in this group.
Monoclonal antibodies combined with hyaluronidase are classified at the same 5th level as the plain monoclonal antibody.
L01X OTHER ANTINEOPLASTIC AGENTS
This group comprises antineoplastic preparations which cannot be classified in the preceding groups.
Last updated: 2024-01-26